- Country of manufactureRussia
- Kind of animalFowl
- Release formSolution
Бромколин - О®
I. GENERAL INFORMATION
Бромколин - О®(Bromcolin - О) - the medicine containing in quality of active ingredients of lincomycin a hydrochloride, colistin sulfate and Bromhexine a hydrochloride.
Represents transparent liquid of light yellow color.
Drug is let out in the form of solution for oral use packaged on 1, 0 l in polyethylene canisters of the corresponding capacity. Polyethylene canisters close carving plastic covers with control of the first opening.
Each canister is marked with the instruction: the manufacturing organization, its address and the trademark, the name of the medicine, the name of active ingredients, a route of administration, number of a series (including date of production), a period of validity, drug volume in the canister, storage conditions, a text "For animals", designations of the standard of the organization also accompany with the application instruction.
Store drug in the closed packaging of the producer separately from forages and foodstuff in dry, protected from light, the place, unavailable to children, at a temperature from 5 °C to 25 °C. A period of validity at observance of storage conditions - 1 year from the date of production. After opening of canisters the remains of drug utilize in accordance with the established procedure. It is forbidden to use medicine after the termination of term of its validity.
II. PHARMACOLOGICAL PROPERTIES
Lincomycin possesses antimicrobic action, showing the greatest activity concerning the majority of gram - positive mikroogranizm, including stafilokokk, streptococci, pneumococci, clostridiums, korinobakteriya, and also mycoplasmas. It is active concerning microorganisms, especially the stafilokokk steady against other antibiotics. Does not affect gram - negative bacteria, mushrooms and viruses. The mechanism of action is connected with a podaleniye of synthesis of protein in microbic cells. The maximum concentration of an antibiotic in blood is reached in 1 hour. Therapeutic concentration remains for 24 hours. Lincomycin gets into all bodies and body tissues, including a bone tissue.
Colistin sulfate is included into group of polymyxins. Works only against gram - negative microorganisms, has bactericidal effect. Colistin, contacting phospholipids of a cytoplasmic membrane of a bacterial cell, increases its permeability that leads to destruction of a cell. It is to the same extent active, as concerning the breeding cells and being at rest. It is removed mainly with excrements. Antibacterial activity of colistin extends to Escherichia coli, Klebsiella spp. , Enterobacter spp. , Salmonella spp. , Shigella spp. , Haemophilus spp. , Brucella spp. , Pseudomonas aeruginosa.
The combination of lincomycin and colistin possesses synergy action.
The acquired bacterial resistance develops very slowly.
The Bromhexine which is a part of drug renders mucolytic (sekretolitichesky) and expectorant action. Reduces viscosity of a bronchial secret thanks to what the spontaneous otkhozhdeniye of a phlegm is facilitated. Bromhexine does not possess proteolytic action thanks to what prevents damage mucous bronchial tubes. The mechanism of action is caused by a depolymerization of mucoproteins and mukosakharid therefore viscosity of a bronchial secret decreases. At a vypoyka it is completely soaked up in 30 minutes after reception. The maximum concentration in blood is reached in 1 hour. Bioavailability makes 80% owing to passing through a liver. Bromhexine gets through a blood - brain and placental barrier. It is excreted by kidneys.
Drug is especially active against a pyocyanic stick and at a septicaemia. Before use it is necessary to check sensitivity of activators to lincomycin and colistin. Drug malotoksichen for hematothermal animals. In the recommended doses, has no the local irritative and sensibilizing effect.
III. USE ORDER
Drug is used at the gastrointestinal infections caused: E. coli, Pseudomonasaeruginosa, Haemophilusspp. , Salmonellaspp. , Pasteurella, Staphylococcusspp. and Streptococcusspp. , Enterobacterspp. , and also at the respiratory diseases caused by gram - positive aerobic bacteria: Staphylococcus spp. Streptococcus spp. , including Streptococcus pneumoniae (except for Enterococcus faecalis), Corynebacterium diphtheriae; anaerobic spore - forming bacteria of Clostridium spp. and also gram - negative anaerobic bacteria: Bacteroides spp. , Mycoplasma spp. , followed by formation of the hardly separated viscous secret: chronic pneumonia, bronchitis, tracheobronchitis, etc.
Drug is used to an agricultural bird orally in a dose of 1 ml on 2 liters of drinking water within 3 - 5 days.
It is not recommended to use drug an animal with a renal failure and the affected liver. It is not necessary to apply along with aminoglycosides (gentamycin, Neomycinum), and also with muscle relaxants and anesthetics (threat of development of paralysis of respiratory muscles).
As contraindication to use serves the heavy renal failure, pregnancy, a lactation and individual hypersensitivity of animals to drug components.
Slaughter of animals on meat is allowed not earlier than through the 7th days after drug phase - out. Meat of animals, by force killed before the expiration of the specified term, can be used for feeding of fur - bearing animals after heat treatment or production of meat and bone meal.
IV. PRECAUTIONARY MEASURES
During the work with the drug Bromkolin - P®sleduyet to follow the general rules of personal hygiene and safety measures provided during the work with medicines for animals.
Use of empty canisters from under drug for the household purposes is forbidden.
Transport packaging: 15 canisters on 1 l